Antimicrobial resistance (AMR) is an escalating global health challenge that threatens the effectiveness of life-saving treatments and routine medical procedures. As bacteria and other pathogens evolve to resist existing drugs, infections that were once easily treatable are becoming increasingly difficult—and sometimes impossible—to cure. With estimates suggesting that AMR could cause up to 10 million deaths annually by 2050, there is an urgent need to develop new therapies, reimagine antibiotic stewardship, and strengthen global surveillance systems. Addressing AMR is not only a medical necessity but a societal responsibility that requires coordinated action across sectors and borders.

As part of our commitment to combating this crisis, we support early-stage research across laboratories in India aimed at understanding AMR and developing innovative solutions. Our funded projects span a range of approaches to tackle hard-to-treat forms of tuberculosis, including strategies targeting dormant bacterial populations and interventions that disrupt bacterial metabolism to render existing treatments more effective.

Through these efforts, we aim to accelerate scientific breakthroughs that can slow the spread of AMR and safeguard public health.

Projects Funded

SERS – based rapid identification of fungal isolates 

Principal Investigator

Vivekanandan Perumal

IIT Delhi

Co-Investigators

  • Prof. Dalip Singh Mehta – IIT Delhi
  • Prof. Anuradha Chowdhary – V. P Chest Institute, Delhi
  • Arijit Pal, PhD – Kusuma School of Biological Sciences, IIT Delhi

Targeting non-replicating drug tolerant M. tuberculosis through a pro-drug strategy 

Principal Investigator

Amit Singh

IISc, Bengaluru

Co-Investigators

  • Harinath Chakrapani – IISER, Pune

Towards Elimination of Mycobacterial Persisters through a Prodrug Approach

Principal Investigator

Amit Singh

IISc, Bengaluru

Co-Investigators

  • Harinath Chakrapani – IISER, Pune

Unraveling the regulatory mechanism that connects ribosome biogenesis and stringent response with bacterial cell growth

Principal Investigator

B. Anand

IIT, Guwahati

Exploring a novel bacterial killing strategy involving mechanical force exerted by host molecular machines 

Principal Investigator

Anirban Banerjee

IIT, Bombay

Intracellular Delivery of the Antimicrobial Peptides for Drug-Resistant Bacterial Infections

Principal Investigator's

Sandhya Ganesan

IISER, Thiruvananthapuram

Rajendra Kurapati

IISER, Thiruvananthapuram

Preclinical evaluation and development of FDA-approved antipsychotic phenothiazine as a drug reposition candidate against Japanese Encephalitis (Phase 1)

Principal Investigator

Manjula Kalia

Regional Centre for Biotechnology, Faridabad

NIPAH virus project: Developing a candidate mRNA vaccine against the Nipah virus 

Principal Investigator

Raghavan Varadarajan

IISc, Bengaluru

Co-Investigators

  • Siddharth Jhunjhunwala – IISc, Bengaluru

  • Mrinmoy De – IISc, Bengaluru

  • Amit Awasthi – THSTI, Faridabad

Metabolic intoxication as a novel strategy for adjuvant therapy to eliminate Mycobacterium tuberculosis

Principal Investigator

Raju Mukherjee

IISER, Tirupati

Co-Investigators

  • Kiran Kumar Pulukuri – IISER, Tirupati

Targeting type III toxin-antitoxin RNP complex assembly as a potential antibacterial strategy

Principal Investigator

Mahavir Singh

IISc, Bengaluru

Tracking AMR transmission risks in rural India across the One Health spectrum.

Principal Investigator

Sitara SR Ajjampur

Christian Medical College, Vellore

Co-Investigators

  • Balaji Veeraraghavan – Christian Medical College, Vellore
  • Rameshchandra J. Pandit – Gujarat Biotechnology Research Centre, Gandhinagar
  • Rajiv Sarkar – Indian Institute of Public Health, Shillong