Neurodegenerative disorders such as Alzheimer’s and Parkinson’s are a growing health challenge in India as the population ages. These conditions gradually impair cognitive and motor functions, profoundly affecting patients and placing significant emotional and economic strain on families and the healthcare system. With limited treatment options and no current cures, advancing research is essential to understand the causes of neurodegeneration, identify early biomarkers, and develop effective interventions.

We support projects that explore innovative approaches in this field, including developing less invasive methods to detect Alzheimer’s disease in older adults, using sensory responses such as smell to identify early markers, and creating new therapeutic strategies to prevent or slow brain degeneration.

Projects Funded

A novel strategy for identification of modifiers and drugs to halt age-dependent trans-cellular propagation of pathogenic tau aggregates and associated impairments

Principal Investigator

Surajit Sarkar

University of Delhi South Campus, New Delhi

Prevention of Ferroptosis by Artificial GPX4: A Novel Strategy for the Treatment of Hemorrhagic stroke

Principal Investigator

G. Mugesh

IISc, Bengaluru

Transforming Nanoscale Molecular Landscape to Delay the onset of Alzheimer’s Disease

Principal Investigator

Deepak Nair

IISc, Bengaluru

Co-Investigators

  • Akkattu T. Biju – IISc, Bengaluru

Mechanistic interrogation of the spinal mechanisms underlying chemotherapy induced neuropathic pain

Principal Investigator

Anupama Sathyamurthy

IISc, Bengaluru

Co-Investigators

  • Arnab Barik – IISc, Bengaluru 

Exploring the role of innate immune cells in Parkinson’s disease 

Principal Investigator

Dipyaman Ganguly

Indian Institute of Chemical Biology, Kolkata

Revealing Circuit Biomarkers in Alzheimer’s Disease using Olfactory Stimulation

Principal Investigator

Debanjan Dasgupta

IIT Kanpur

Co-Investigators

  • Ashutosh Modi – IIT Kanpur

A Dual-Platform Approach Combining Raman Spectroscopy and Proteomics for Minimally-Invasive Biomarker Discovery in Alzheimer’s Disease: A Focus on the Elderly Population of South India 

Principal Investigator

Baby Chakrapani P S

Cochin University of Science and Technology, Cochin

Co-Investigators

  • Yoosaf Karuvath – Cochin University of Science and Technology, Cochin
  • Tara Sudhadevi – Cochin University of Science and Technology, Cochin
  • Keshava Prasad T S – Yenepoya Deemed to be University, Mangalore

β-phenylethylamine (β-PEA) and TAAR-1 pathway as a plausible pharmacological target against Huntington’s disease

Principal Investigator

Bhavani Shankar Sahu

National Brain Research Centre, Gurgaon